O‘ZBEKISTONDA O‘SADIGAN BIR YILLIK SHUVOQ O‘SIMLIGIDAN(ARTEMISIA ANNUA L.) ARTEMIZININNI AJRATIB OLISHNING TAKOMILLASHTIRILGAN USULI
Kalit so‘zlar:
COVID-19, SARS-2-CoV-2, коронавируслар, фитопрепаратлар, Бир йиллик шувоқ, Artemisia annua L., артемизинин, экстракция, ИҚ-спектр, масс-спектр.Annotatsiya
Artemisia annua L. o‘simligining turli geografik mintaqalardagi vakillarining kimyoviy tarkibi, xususan, Artemizinin miqdori o‘rganilgan. Lekin, O‘zbekistonda o‘sadigan vakillarining kimyoviy tarkibi o‘rganilmagan. Mazkur tadqiqotda O‘zbekistonda, xususan, Farg‘ona vodiysida o‘sadigan Artemisia annua L.o‘simligidan Artemizininni ajratib olish va miqdorini aniqlash maqsad qilingan.Artemisia annua L.o‘simligidan Artemizininni ajratib olishda organik erituvchilarda ekstraksiya qilish, ajratib olingan moddaning fizik-kimyoviy ko‘rsatkichlari, kimyoviy tarkibi hamda tuzilishini aniqlashda yupqa qatlamli va ustunli xromatografiya, IQ, mass-spektrometriya usullari qo‘llanilgan. Farg‘ona vodiysida o‘sadigan Artemisia annua L.o‘simligidan organik erituvchilarni almashtirish orqali 1,2-1,5 % gacha Artemizininni ajratib olishga erishildi. Petroley efirda ektraksiya jarayoni turli vaqtlarda olib borildi. Ekstraksiya vaqti 2 sutkadan ortganda unum sezilarli o‘zgarmasligi aniqlandi. Olingan moddaning IQ- va mass-spektrlari tahlil qilinganda tuzlishi artemizininning tuzilishiga mos kelishi kuzatildi.Shunday qilib, birinchi marta O‘zbekistonda, Farg’ona vodiysida o‘sadigan Artemisia annua L.o‘simligidan Artemizinin biologik faol moddasini toza holda ajratib olindi. Ektraksiya va tozalash metodikasi takomillashtirildi hamda umumiy unumning 1,5 % gacha oshirilishiga erishildi.
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