SILYBUM MARIANUM (L.) GAERTN. O‘SIMLIGINING KIMYOVIY TARKIBI VA AHAMIYATI

Muzaffar Obidov

Biology

No. 3 (2024): FarDU.Ilmiy xabarlar jurnali. Ilova to'plam (Aniq va tabiiy fanlar)

SYLYBUM MARIANUM (L.) GAERTN. CHEMICAL COMPOSITION AND SIGNIFICANCE OF THE PLANT

Muzaffar Obidov ^▸^▾

PDF (Uzbek)

Submitted: August 17, 2024
Published: 2024-09-12

Abstract

This species has been used in folk medicine for over 2000 years as a medicinal plant against liver, kidney, rheumatism, gastrointestinal and heart diseases. In modern medicine, it is widely used as a protective agent against biological and chemical poisoning. This article provides information on the chemical composition of the medicinal plant, its importance in folk and modern medicine, as well as the use of drugs prepared from its various organs.

References

Emadi SA, Ghasemzadeh Rahbardar M, Mehri S, Hosseinzadeh H. A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents. Iran J Basic Med Sci. 2022 Oct;25(10):1166-1176.
Bombardelli E, Korti F, inventors. Compositions for treatment of fatigue related to cancer. Russia patent RU2631612C2. 2017 Sep 25.
Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IH. Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice. Cancer Lett. 2012;326:88–95.
Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther. 2010;332:1081–1087.
Chambers CS, Holečková V, Petrásková L, Biedermann D, Valentová K, Buchta M, et al. The silymarin composition… and why does it matter? Food Res Int. 2017;100:339–353.
Claudio L, Massimo R, inventors. D’Amatoulrich M, Mengsralf-Tosten, French PP, inventors. Silibinin component for the treatment of hepatitis. Japan patent JP5349486B2. 2013 Nov 20;
Cornblatt B, Cornblatt G, inventors. Compositions comprising sulforaphane or a sulforaphane precursor and a milk thistle extract or powder. Taiwan patent TW201402129A. 2014 Jan 16;

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[1] Emadi SA, Ghasemzadeh Rahbardar M, Mehri S, Hosseinzadeh H. A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents. Iran J Basic Med Sci. 2022 Oct;25(10):1166-1176.

[2] Bombardelli E, Korti F, inventors. Compositions for treatment of fatigue related to cancer. Russia patent RU2631612C2. 2017 Sep 25.

[3] Brandon-Warner E, Eheim AL, Foureau DM, Walling TL, Schrum LW, McKillop IH. Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice. Cancer Lett. 2012;326:88–95.

[4] Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther. 2010;332:1081–1087.

[5] Chambers CS, Holečková V, Petrásková L, Biedermann D, Valentová K, Buchta M, et al. The silymarin composition… and why does it matter? Food Res Int. 2017;100:339–353.

[6] Claudio L, Massimo R, inventors. D’Amatoulrich M, Mengsralf-Tosten, French PP, inventors. Silibinin component for the treatment of hepatitis. Japan patent JP5349486B2. 2013 Nov 20;

[7] Cornblatt B, Cornblatt G, inventors. Compositions comprising sulforaphane or a sulforaphane precursor and a milk thistle extract or powder. Taiwan patent TW201402129A. 2014 Jan 16;