logo
O‘zbekcha

METHODS FOR DETERMINING THE ACUTE POISONING AND CUMULATIVE PROPERTIES OF A NATURAL REMEDY “AS-SULTAN”

Mualliflar

Kalit so‘zlar:

Keywords. Acute toxicity, spasm, Student's t-test, cumulative, coefficient, “open area”.

Annotatsiya

Based on local plants a new biologically active food additive developed As-Sultan – a natural food supplement that replaces certain synthetic drugs that help prevent and treat gallbladder inflammation acute toxicity and Preclinical tests were conducted to determine the cumulative properties. According to the results of the experiments, it was determined that the average lethal dose of the As-Sultan food additive is LD50>10000 mg/kg. The chemical compounds were classified as belonging to the relatively harmless VI class of acute toxicity. It was proven that they do not have a cumulative property.

Mualliflar haqida

  • Ibrohimjon Askarov, Andijan State University

    Professor of the Chemistry faculty, Andijan State University, Doctor of Chemical Sciences, Honored Inventor of Uzbekistan, Chairman of the Academy of Medicine of Uzbekistan

  • Maksadbek Khojimatov, Andijan State University

    Professor of the Chemistry faculty, Andijan State University, Doctor of Chemical Sciences

  • Dilnoza Khojimatova, Andijan State University

    Andijan State University, Senior Lecturer of the Chemistry faculty, Doctor of Philosophy (PhD) in Chemistry

Adabiyotlar

I.R. Askarov. Mysterious medicine// T.: Science and Technology Publishing House. 2021. 1010 p.

Askarov IR Dictionary of Medicine. Classic word. Tashkent – 2019., -P. 1142.

Papp N., Bartha S., Boris G., Balogh L. Traditional uses of medicinal plants for respiratory diseases in Transylvania. Nat. Prod. Commun. 2011;6:1459–1460. doi: 10.1177/1934578X1100601012. [PubMed] [CrossRef] [Google Scholar].

Sadasivan KP, Katsumi K, Mathews M, Thomson M, Bhavana S, Parvathy S. John WilliamTrevan’s Concept on Median Lethal Dose (LD50/LC50)- More Misused than Used. J Pre-Clin clin Res. doi: 10.26444/jpccr/139588. 15.07.2021

Erhirhie EO, Ihekwereme, CP, Ilodigwe EE. Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance. Interdiscip Toxicol. 2018; 11: 5–12

Karabayeva Z.T. Toksikologiya. Darslik. “Nurafshon business” nashriyoti, «Toshkent kimyo-tehnologiya» bosmаxonаsidа chop etildi. 2019, -277 b.

Nouioura G., Tourabi M., Tahraoui A. Assessment of the acute and subacute toxicity of the aqueous extract of Moroccan Ferula communis fruit in a mouse model // Saudi Pharmaceutical Journal. Volume 31, Issue 8, 2023.

Erhirhie EO, Ihekwereme CP, Ilodigwe EE Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance// Interdiscip Toxicol. 2018;11(1):5-12. doi:10.2478/intox-2018-0001

Management of medical research. Chast pervaya//Pod ed. Mironova A.N.- M.-2012.-p.13-27.

Yuklab olishlar

Nashr etilgan

2025-04-25

Qanday iqtibos keltirish

METHODS FOR DETERMINING THE ACUTE POISONING AND CUMULATIVE PROPERTIES OF A NATURAL REMEDY “AS-SULTAN”. (2025). Scientific Journal of the Fergana State University, 31(2), 198. https://journal.fdu.uz/index.php/sjfsu/article/view/6505