EVALUATION OF THE EFFECT OF BUCKWHEAT ON SMALL INTESTINAL FUNCTION BASED ON IN SILICO ANALYSIS

doi:10.56292/SJFSU/vol31_iss3/a%p

Authors

O'zbekiston Respublikasi Fanlar Akademiyasi

https://orcid.org/0009-0001-9021-6782
Toshkent kimyo texnologiya instituti

https://orcid.org/0000-0002-8120-3728

DOI:

https://doi.org/10.56292/SJFSU/vol31_iss3/a%25p

Keywords:

buckwheat, small intestine, flavonoids, rutin, quercetin, molecular docking, pharmacokinetics, pkCSM, ADME/Tox, protease, digestion

Abstract

Buckwheat (Fagopyrum esculentum) is rich in biologically active substances and has a positive effect on the intestinal microflora and digestive processes. In this study, the effect of buckwheat components, in particular flavonoids (rutin and quercetin), on small intestinal enzymes was evaluated using molecular docking in the CB-Dock program. The docking results showed that rutin and quercetin form stable bonds with intestinal proteases, which can change their enzymatic activity. The pkCSM ADME/Tox platform was used to evaluate the pharmacokinetic and toxicological properties. According to the results, these flavonoids are relatively well absorbed from the intestine, do not have toxic effects, and are safely metabolized in the body. The results of the study indicate the need for further study of the beneficial properties of buckwheat for the digestive system.

Author Biographies

, O'zbekiston Respublikasi Fanlar Akademiyasi

O'zbekiston Respublikasi Fanlar Akademiyasi, bioorganik kimyo instituti k.f.n, dotsent
, Toshkent kimyo texnologiya instituti

Toshkent kimyo-texnologiya instituti, (PhD)

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