sg

Chemistry

No. 1 (2023): Scientific journal of the Fergana State University (Exact and natural sciences)

CHEMICAL COMPONENTS OF MELILOTUS OFFICINALIS AND MELILOTUS ALBUS, GROWING IN UZBEKISTAN

Submitted
June 26, 2023
Published
2023-07-05

Abstract

The article is devoted to the study of the chemical components of the aboveground part of the medicinal plant Melilotus officinalis (L.) Pall (sweet clover) and Melilotus albus of the Fabaceae family Three phenolic compounds were isolated from chloroform-ethyl acetate fractions of 75% alcohol extract of the above-ground part of Melilotus officinalis. Based on the study of UV, 1H, 13C NMR, HSQC, and HMBC spectra, the isolated substances were identified with dihydrocoumarin, melilotic acid, and E-melilotoside.

The component composition of the essential oil of the air-dry aerial part of Melilotus albus obtained by hydrodistillation was studied by the GC-MS. The main component of the essential oil is coumarin, which content is 97.92%.

References

  1. Rastitel'nyye resursy SSSR: Tsvetkovyye rasteniya, ikh khimicheskiy sostav, ispol'zo- vaniye. Semeystva Hydrangeaceae – Haloragaceae. L., 1987. S.159–161.
  2. Khalmatov Kh.Kh., Kharlamov I.A., Alimbayeva P.K., Karryyev M.O., Khaitov I.Kh. Osnovnyye lekarstvennyye rasteniya Sredney Azii. Tashkent, 1984. S. 60–61
  3. Kurkin V.A. Farmakognoziya. Samara, 2007. C. 733-735.
  4. Sokolov S.Y. Fitoterapiya i fitofarmakologiya: Rukovodstvo dlya vrachey. M.: Medi- tsinskoye informatsionnoye agentstvo, 2000, S.181-183.
  5. Putyrskiy I.N., Prokhorov V.N. Universal'naya entsiklopediya lekarstvennykh rasteniy. M., 2000. 120-122 s.
  6. Al-Snafi A.E. Chemical Constituents and Pharmacological Effects of Melilotus оfficinalis – A Review //IOSR Journal of Pharmacy. 2020. V. 10 (1). Pp. 26–36.
  7. Kharlampovich T.A. Fitokhimicheskoye izucheniye i standartizatsiya donnika lekarstvennogo travy, proizrastayushchey na territorii Altayskogo kraya: avtoref. diss. … kand. farm.nauk. Perm'. 2014. 21 c.
  8. Mullazhonova M.T. Farmakognosticheskoye izucheniye donnika lekarstvennogo, proizras- tayushchego v Uzbekistane: avtoref. diss. ... kand. farm. nauk. Tashkent, 2007. 23 s.
  9. Hrudʹko I.V. Farmakohnostychne doslidzhennya vydi v rodu Melilotus L. flory Ukrayiny: avtoref. dys. ... kand. farm. nauk. Kharkiv, 2013. 20 s.
  10. Lokteva O.M. Farmakologicheskaya kharakteristika ekstrakta donnika: avtoref. dis. . kand; biol. Nauk, SPb, 1999. 20 s.
  11. Liu Y.T., Gong P.H., Xiao F.Q., Shao S., Zhao D.Q., Yan M.M., Yang X.W. Chemical constituents and antioxidant, anti-inflammatory and anti-tumor activities of Melilotus officinalis (Linn.) Pall. //Molecules. 2018. V. 23. N2. P. 271.
  12. Sisay M. A., Mammo W., Yaya E. E. Phytochemical studies of Melilotus officinalis. //Bull. Chem. Soc. Ethiop. 2021. V. 35(1). Рр. 141-150
  13. Yang J., Wang L.L., Zhang T.J. Research progress on chemical constituents in plants of Melilotus Linn. and their pharmacological activities. //Chin Tradit Herb Drugs. 2014. V. 45. №2. Pp. 447-454.
  14. Usmanova N.K., Bobakulov H.M., Karimov A.M., Sasmakov S.A., Botirov E.H., Azimova Sh.S., Abdullaev N.D. Component composition and antimicrobial activity of the essential oil of Melilotus officinalis (L.) Pall, grown in Uzbekistan. // Khimiya rastitel'nogo syr'ya. 2022. No. 1. P.161-168.
  15. Usmanova N., Ermatov R., Karimov A., Botirov E. Khimicheskiye komponenty lekarstvennogo rasteniya Melilotus officinalis (L.) Pall. //Vestnik NUUz. Yestestvennyye nauki. 2022. № 3/1. S. 328-330.
  16. Usmanova N. K., Khurramov A. R., Bobakulov Kh. M., Botirov E. Kh. Constituents of the medicinal plant Melilotus officinalis. //Chem. Nat. Compd. 2022. V. 58, No. 6. Рр. 1129-1130.
  17. Usmanova N.K., Botirov E.KH. Khimicheskiye komponenty donnika lekarstvennogo – Melilotus officinalis (L.) Pall. //Nauchnyy vestnik FerGU. 2022. №5. C. 246-250.
  18. Zykova I.D., Yefremov A.A. Komponentnyy sostav efirnogo masla Melilotus albus medicus (Fabaceae). //Khimiya rastitel'nogo syr'ya. 2012. №4. S.109-112.
  19. S. Serra, A. Castagna, M. Valentino. Biocatalytic Synthesis of Natural Dihydrocoumarin by Microbial Reduction of Coumarin. //Catalysts. 2019. V. 9. P. 665.
  20. F.H. Afshar, A. Delazar, H.n Nazemiyeh, L. Nahar, S. B. Moghaddam, B. O. Mbaebie, S. Gibbons, S. D. Sarker. Melilotoside Derivatives from Artemisia splendens (Asteraceae) //Rec. Nat. Prod. 2017. 11:1 43-50
  21. Adams R.P. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, ed. 4.1. Allured Publishing Corporation, Carol Stream, Illinois, 2017. 804p.
  22. Babushok V.I., Linstrom P.J., Zenkevich I.G.J. Retention Indices for Frequently Reported Compounds of Plant Essential Oils //Phus. Chem. Ref. Data. 2011. V. 40. №4. 043101.