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Chemistry

No. 3 (2024): FarDU.Ilmiy xabarlar jurnali (Aniq va tabiiy fanlar)

SYNTHESIS OF 2-SUBSTITUTED 3(H)-QUINAZOLIN-4-ONE DERIVATIVES AND THEIR NITRATION REACTIONS

Submitted
July 25, 2024
Published
2024-07-30

Abstract

In this research work, the synthesis of 2-substituted derivatives of 3(H)-quinazoline-4-one was studied, as well as factors that have a major influence on the reaction process and product yield (ratio of substances, temperature, time), physico-chemical values of the synthesized compounds. Nitration reactions of synthesized 3(H)-quinazoline-4-one 2-substituted derivatives were carried out using a nitrating mixture (HNO3+H2SO4). As a result of electrophilic addition reactions of 2-substituted 3(H)-6-nitroquinazoline-4-ones alternating with the -NO2 group of a mobile hydrogen atom located in the sixth position of the benzene chain, 2-substituted 3(H)-quinazoline-4-ones, respectively, synthesize 2-substituted 3(H)-6-nitroquinazoline-4-one. Quantitative determination of synthesized compounds by spectrophotometric analysis was carried out on the SF-46 device. A solution of 0.1 mol/l HCl was used as a solvent. The course of the reaction and the formation of the product were controlled by thin-layer chromatography. The structure of the synthesized compounds was determined and analyzed by IR, 1H, 13C NMR spectroscopy methods.

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