2-ALMASHGAN 3(H)-XINAZOLIN-4-ON HOSILALARI SINTEZI VA ULARNI NITROLASH REAKSIYALARI

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Nashr qilingan: iyl 30, 2024
Kalit so‘zlar:
3(H)-xinazolin-4-on, geteroxalqali birikma, siklokondensatsiya, nitrolovchi aralashma, biologik faol, sintez, katalizator, xarorat, reaksiya davomiyligi, faollantirilgan ko‘mir, xromatografiya, spektroskopiya, qayta kristallash.

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Ziyadullayev Mirjalol Egamberdi o‘g‘li
Chirchiq davlat pedagogika universiteti
https://orcid.org/0000-0001-7476-7202
Karimov Rixsiboy Kuchkarovich
Toshkent kimyo texnologiya instituti
https://orcid.org/0000-0002-2551-1531
Adilboyev Samariddin Xolmirza o‘g‘li
Chirchiq davlat pedagogika universiteti
https://orcid.org/0009-0001-7179-523X

Annotatsiya

Ushbu tadqiqot ishida 3(H)-xinazolin-4-onning 2-almashgan hosilalari sintezi hamda reaksiya jarayoni va mahsulot unumiga asosiy ta’sir etuvchi (moddalar nisbati, harorat, vaqt) omillar, sintez qilingan birikmalarning fizik-kimyoviy kattaliklari o‘rganilgan. Sintez qilingan 3(H)-xinazolin-4-onning 2-almashgan hosilalarini nitrolovchi aralashmadan (HNO3+H2SO4) foydalangan holda nitrolash reaksiyalari olib borilgan. Natijada 2-almashgan 3(H)-xinazolin-4-onlarning tarkibidagi benzol xalqasining oltinchi holatida joylashgan harakatchan vodorod atomining -NO2 guruhiga almashib elektrofil birikish reaksiyalari natijasida mos ravishdagi 2-almashgan 3(H)-6-nitroxinazolin-4-onlar sintez qilingan. Sintez qilingan birikmalarni miqdoriy aniqlash spektrofotometrik analiz usuli SF-46 qurilmasida olib borilgan. Erituvchi sifatida 0,1 mol/l HCl eritmasi ishlatilgan. Reaksiya jarayonining borishi va mahsulot hosil bo‘lishi yupqa qatlamli xromatografiya usulida nazorat qilingan. Sintez qilingan birikmalarning tuzilishi IQ, 1H, 13C YaMR spektroskopiya usullarida aniqlangan va tahlil qilingan.

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Qanday qilib iqtibos keltirish kerak
Ziyadullayev , M., Karimov , R., & Adilboyev , S. (2024). 2-ALMASHGAN 3(H)-XINAZOLIN-4-ON HOSILALARI SINTEZI VA ULARNI NITROLASH REAKSIYALARI. Farg’ona Davlat Universiteti, 30(3), 151. Retrieved from https://journal.fdu.uz/index.php/sjfsu/article/view/4401
Maqola
№. 3 (2024): FarDU.Ilmiy xabarlar jurnali (Aniq va tabiiy fanlar)
Bo‘lim
Kimyo
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Mualliflar biografiyasi

Ziyadullayev Mirjalol Egamberdi o‘g‘li, Chirchiq davlat pedagogika universiteti

Chirchiq davlat pedagogika universiteti, Fizika va kimyo fakulteti Kimyo kafedrasi dotsenti, kimyo fanlari falsafa bo‘yicha doktori (PhD)

“Alfraganus university” Nodavlat oliy ta’lim tashkiloti, Tibbiyot fakulteti, Kimyo va farmasevtika kafedrasi dotsenti, kimyo fanlari falsafa bo‘yicha doktori (PhD)

Karimov Rixsiboy Kuchkarovich, Toshkent kimyo texnologiya instituti

Toshkent kimyo texnologiya instituti, Yoqilg‘i organik birikmalar kimyoviy texnologiyasi fakulteti, Asosiy organik sintez kafedrasi, texnika fanlari doktori, professor. O‘simlik moddalari kimyosi instituti, Sintetik preparatlar texnologiyasi laboratoriyasi katta ilmiy xodimi, texnika fanlari doktori, professor

Adilboyev Samariddin Xolmirza o‘g‘li, Chirchiq davlat pedagogika universiteti

Chirchiq davlat pedagogika universiteti, Fizika va kimyo fakulteti Kimyo kafedrasi magistranti

Foydalaniladigan adabiyotlar

ADABIYOTLAR RO‘YXATI

Samir Y. Abbas. Book. 3(H)-Quinazolinone Derivatives: Syntheses, Physical Properties, Chemical Reaction, and Biological Properties. Sana'a University, Yemen. 06.06.2020. 126 pp.

B. Ramua, P. Malles and K. Sudhakar babu. Synthesis, characterization and biological studies of quinazoline based heterocyclic Schiff base and its transition metal complexes. Heterocyclic Letters Vol. 11. No.4. 657-666 pp. August-October 2021

David S.A. Haneen, Rasha S. Gouhar, Heba E. Hashem, Ahmed S. A. Youssef (2019). Synthesis and reactions of 4H-3,1-benzoxazin-4-one derivative bearing pyrazolyl moiety as antimicrobial and antioxidant agents. Synthetic Communications, 1.

Yu.V.Martynenko, M.S.Kazunin, I.S.Nosulenko, G.G.Berest, S.I. Kovalenko, O.M.Kamyshnyi, N.M.Polishchuk. 2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-,aryl-)-amines and their derivatives. The synthesis of (3Н-quinazoline-4-ylidene) hydrazides N-protected aminoacids, using a variety of amine-protecting approaches. Physical-chemical properties and biological activity of synthesized compounds // Zaporozhye medical journal, 2018. Volume 20. No 3. –pp. 413-420.

Vasily N. Osipov, Derenik S. Khachatryan, Alexandr N. Balaev. Biologically active quinazoline-based hydroxamic acids. Medicinal Chemistry Research 2020. Vol. 29, No.5. –pp. 831-845.

Lawaniya, Y.K., & Goyal, P.K. (2022). Synthesis of Novel Quinazolin-4-one hybrids as potential antimicrobial agents. International Journal of Health Sciences, 6(S2), pp. 6042-6054.

M. Komar., M. Molnar, M. Jukiс, L.G. Obrovac, T.O.Bernardi. Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation // Green Chemistry Letters and Reviews, 2020, Volume 13, No. 2. –pp. 93-101.

Abdel-Monem. M. F. Eissa, Kouser. A. Hebash, Mohamed Abo Riya and Sherif. I. M. Ramadan. Synthesis and Reactivity of 6-Iodo-4H-3,1-Benzoxazin-4-one Towards Nitrogen Nucleophiles and Their Antimicrobial Activities. Chemical and Process Engineering Research www.iiste.org. ISSN 2224-7467 (Paper) ISSN 2225-0913 (Online). Vol. 15. 2013. pp. 18-27.

Katherine Chae Jahng, Seung Ill Kim, Dong Hyeon Kim, Chang Seob Seo, Jong-Keun Son, Seung Ho Lee, Eung Seok LEE, and Yurngdong Jahng. One-Pot Synthesis of Simple Alkaloids: 2,3-Polymethylene-4(3H)-quinazolinones, Luotonin A, Tryptanthrin, and Rutaecarpine // Chem. Pharm. Bull. 2008. 56(4) –pp. 607-609.

Ashraf A Aly, Esam A. Ishak, Mohamed Ramadan, Mousa O. Germoush, Talaat I. El-Emary, and Nayef S. Al-Muaikelg, Recent Report on Thieno[2,3-d]pyrimidines. Their Preparation Including Microwave and Their Utilities in Fused Heterocycles Synthesis J. Heterocyclic Chem., 2013, 50, –pp. 451-472.

P.O. Osarumwense, M.O. Edema, C.O. Usifoh. Synthesis And Anagesic activities of Quinazolin-4(3H)-one, 2-Methyl-4(3H)-Quinazolinone and 2-Phenyl-4(3H)-quinazolin-4(3H)–one. Journal of Drug Delivery & Therapeutics. Vol 10 No 4-s (2020): Volume 10, Issue 4-s, July-August 2020.

Khalida Al-Azawi. Synthesis, Characterization and Antioxidant Studies of Quinazolin Derivatives. Oriental Journal of Chemistry. 05 Feb 2016.

Alafeefy A.M. Some new quinazolin-4(3H)-one derivatives, synthesis and antitumoractivity // Journal of Saudi Chemical Society, 2011, №15. –pp. 337-343.

Г.А.Швехгеймер. Синтез гетероциклических соединений на основе изатовых ангидридов (2Н-3,1-бензоксазин-2,4-дионов // Химия гетероциклическое соединений, 2001, №4. –С. 435-491.

Зиядуллаев, М. Э. У., Каримов, Р. К., Зухурова, Г. В., Абдуразаков, А. Ш., & Сагдуллаев, Ш. Ш. (2020). Оптимизация процесса синтеза 6-нитро-3, 4-дигидрохиназолин-4-она. Известия высших учебных заведений. Химия и химическая технология, 63(7), 48-53.