DALACHOY TARKIBIDAGI VITAMINLAR MIQDORINI ANIQLASH VA ULARNING ORGANIZMGA TA’SIRI
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Annotatsiya
Hozirgi kunga kelib, o‘simliklardan tayyorlangan tabiiy-dori vositalariga qiziqish va ehtiyoj ortib boryapti. Butun dunyoda bemorlarni davolashda o‘simliklardan tayorlangan tabiiy-dori vositalar va oziq-ovqat qo‘shilmalaridan foydalanish Yevropa davlatlarida yuqori ko‘rsatkichlarni tashkil qiladi. Ayniqsa Germaniyada davolashda o‘simliklardan foydalanish organizmga sintetik dori vositalaridan ko‘ra foydaliroq ta’sirga ega ekanligini allaqachon tushunib yetishgan. Osiyoda joylashgan yirik rivojlangan davlatlar Yaponiya va Xitoyning tibbiyotda o‘simliklardan keng foydalanishi hechkimga sir emas. Shuning uchun biz dalachoydan oziq-ovqat qo‘shilmasi yaratish maqsadida, tarkibidagi vitaminlarni suyuqlik xromatografiyasi usuli yordamida aniqlandi. Tajriba davomida Dalachoy tarkibida B1,B2,B3,B6 va B9 vitaminlari aniqlandi. Antioksidant vitaminlardan vitamin Sning aniqlanishi dalachoyni teri regeneratsiyasida va qarish jarayonlarini oldini olishda ijobiy ta’siri borligidan dalolatdir.
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Foydalaniladigan adabiyotlar
Daniels SR, Gidding SS, de Ferranti SD. Pediatric aspects of familial hypercholesterolemias: recommendations from thуe National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol. 2011;5:S30–S37. doi: 10.1016/j.jacl.2011.03.453. [PubMed] [CrossRef] [Google Scholar]
McNeal CJ, Dajani T, Wilson D, Cassidy-Bushrow AE, Dickerson JB, Ory M. Hypercholesterolemia in Youth: Opportunities and obstacles to prevent premature atherosclerotic cardiovascular disease. Curr Atheroscler Rep. 2010;12:20–28. doi: 10.1007/s11883-009-0072-0. [PubMed] [CrossRef] [Google Scholar]
Booth A. A., Khalifah R. G., Hudson B. G. Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison witn aminoguanidine // Biochem. Biophys. Res. Comm., 1996; 220: 113–119.
Thiamine corrects delayed replication and decreased production of lactate and advanced glycation endproducts in bovine retinal and umbilical vein endothelial cells cultured under high-glucose conditions / M. la Selva [et al.] // Diabetologia, 1996; 39: 1263–1268.
Thornalley P. J. The potential role of thiamine (vitamin B1) in diabetic complications // Curr. Diabetes Rev., 2005; 1: 287–298.
Lohmann,K.and Schuster, P., Biochem. Z., 1937, vol. 294, pp. 188–214.
Strumilo,S.,Acta.Biochim.Pol.,2005,vol.52,pp.759– 764.
Lonsdale D.— Thiamine metabolism in disease. CRC Crit Rev in Clin Lab Sci, 1975, 5, 289-313.
Cardoso, D.R.; Libardi, S.H.; Skibsted, L.H. Riboflavin as a photosensitizer. Effects on human health and food quality. Food Funct. 2012, 3, 487–502. [Google Scholar] [CrossRef]
Buehler, B.A. Vitamin B2: Riboflavin. J. Evid. Based. Complementary Altern. Med. 2011, 16, 88–90. [Google Scholar] [CrossRef]
Toyasaki, T. Antioxidant effect of riboflavin in enzymic lipid peroxidation. J. Agric. Food Chem. 1992, 40, 1727–1730. [Google Scholar] [CrossRef]
Zou, Y.; Ruan, M.; Luan, J.; Feng, X.; Chen, S.; Chu, Z. Anti-aging effect of riboflavin via endogenous antioxidant in fruit fly Drosophila melanogaster. J. Nutr. Health Aging 2015, 21, 314–319. [Google Scholar] [CrossRef] [PubMed]
Cheung, I.M.Y.; Mcghee, C.N.J.; Sherwin, T. Beneficial effect of the antioxidant riboflavin on gene expression of extracellular matirix elements, antioxidants and oxidases in keratoconic stromal cells. Clin. Exp. Optom. 2014, 97, 349–355. [Google Scholar] [PubMed]
Pompella, A.; Visvikis, A.; Paolicchi, A.; De Tata, V.; Casini, A.F. The changing faces of glutathione, a cellular protagonist. Biochem. Pharmacol. 2003, 66, 1499–1503. [Google Scholar] [CrossRef]
Altschul.R, Hoffer.A, Stephen.J.D.,1955. Influence of nicotinic acid on serum cholesterol in man. Arch.Biochem.54,558-559.
89.Keener.V.S,Sanossian.N.,2008.Niacin for stroke prevention: evidence and rationale. CNC Neurosci. Ther.14, 287-294.
Boyonoski.A.C., Spronck.J.C.,Jacobs.R.M.,Shah.G.M.,Poirier.G.G.,Kirkland.J.B., 2002b. Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of enthylnitrosourea-induced carcinogenesis in rats. J.Nutr. 132,115-120.
Birch T.W., Gyorgy P., Harris L.J. The vitamin B(2) complex. Differentiation of the antiblacktongue and the "P.-P." factors from lactoflavin and vitamin B(6) (so-called "rat pellagra" factor). Parts I-VI. Biochem. J. 1935;29:2830–2850. [PMC free article] [PubMed] [Google Scholar]
Per Magne Ueland , Adrian McCann, Øivind Midttun, Arve Ulvik. Inflammation, vitamin B6 and related pathways.Mol Aspects Med. 2017 №53.Р.10-27. DOI: 10.1016/j.mam.2016.08.001
Ishihara J., Iso H., Inoue M., Iwasaki M., Okada K., Kita Y., Kokubo Y., Okayama A., Tsugane S. Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. J. Am. Coll. Nutr. 2008;27:127–136. [PubMed] [Google Scholar]
Lal K.J., Dakshinamurti K., Thliveris J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J. Hypertens. 1996;14:355–363. doi: 10.1097/00004872-199603000-00013. [PubMed] [CrossRef] [Google Scholar]
Dakshinamurti K., Dakshinamurti S. Blood pressure regulation and micronutrients. Nutr. Res. Rev. 2001;14:3–44. doi: 10.1079/095442201108729123. [PubMed] [CrossRef] [Google Scholar]
Okuda T., Sumiya T., Iwai N., Miyata T. Pyridoxine 5'-phosphate oxidase is a candidate gene responsible for hypertension in Dahl-S rats. Biochem. Biophys. Res. Commun. 2004;313:647–53. doi: 10.1016/j.bbrc.2003.11.149. [PubMed] [CrossRef] [Google Scholar]
Czeizel A.E., Puho E., Banhidy F., Acs N. Oral pyridoxine during pregnancy : potential protective effect for cardiovascular malformations. Drugs R. D. 2004;5:259–269. doi: 10.2165/00126839-200405050-00002. [PubMed] [CrossRef] [Google Scholar]
Merrill R.M., Taylor P., Aldana S.G. Coronary Health Improvement Project (CHIP) is associated with improved nutrient intake and decreased depression. Nutrition. 2008;24:314–321. doi: 10.1016/j.nut.2007.12.011. [PubMed] [CrossRef] [Google Scholar]
MacKenzie K.E., Wiltshire E.J., Gent R., Hirte C., Piotto L., Couper J.J. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics. 2006;118:242–253. doi: 10.1542/peds.2005-2143. [PubMed] [CrossRef] [Google Scholar]
Nakamura S., Li H., Adijiang A., Pischetsrieder M., Niwa T. Pyridoxal phosphate prevents progression of diabetic nephropathy. Nephrol. Dial. Transplant. 2007;22:2165–2174. doi: 10.1093/ndt/gfm166. [PubMed] [CrossRef] [Google Scholar]
Graham, I. M., Daly, L. E., Refsum, H. M., Robinson, K., Brattstrom, L. E., Ueland, P. M., € et al. (1997). Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. Journal of the American Medical Association, 277, 1775–1781.
LeBlanc, J. G., de Giori, G. S., Smid, E. J., Hugenholtz, J., & Sesma, F. (2007). Folate production by lactic acid bacteria and other food-grade microorganisms. Communicating Current Research and Educational Topics and Trends in Applied Microbiology, 1, 329–339.
Pfeiffer, C. M., Caudill, S. P., Gunter, E. W., Osterloh, J., & Sampson, E. J. (2005). Biochemical indicators of B vitamin status in the US population after folic acid fortification:Results from the National Health and Nutrition Examination Survey 1999–2000. The American Journal of Clinical Nutrition, 82, 442–450.
Laurence, K. M., James, N., Miller, M. H., Tennant, G. B., & Campbell, H. (1981). Doubleblind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. British Medical Journal (Clinical Research Edition), 282, 1509–1511.
. Scott, J., & Weir, D. (1993). Folate/vitamin B12 inter-relationships. Essays in Biochemistry,28, 63–72
Seller, M. J., & Nevin, N. C. (1984). Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland. Journal of Medical Genetics, 21, 325–330.
Vergel, R. G., Sanchez, L. R., Heredero, B. L., Rodriguez, P. L., & Martinez, A. J.(1990). Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenatal Diagnosis, 10, 149–152.
Levine, M, Conry-Cantilena, C, Wang, Y, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 93, 3704–3709.Google Scholar
Leggott, PJ, Robertson, PB, Rothman, DL, et al. (1986) The effect of controlled ascorbic acid depletion and supplementation on periodontal health. J Periodontol 57, 480–485.Google Scholar
Gale, CR, Martyn, CN, Winter, PD, et al. (1995) Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. BMJ 310, 1563–1566.Google Scholar