BIOLOGIK FAOLLIKGA EGA 1,2,3-TRIAZOL HOSILALARINING SINTEZI

Malika Yakubxodjaeva; Mehribon Pirimova

doi:10.56292/SJFSU/vol31_iss4/a128

Authors

Razakovna

Toshkent davlat stomatologiya instituti

https://orcid.org/0009-0007-6731-6551
Asror qizi

Toshkent davlat stomatologiya instituti

https://orcid.org/0009-0006-5289-2436

DOI:

https://doi.org/10.56292/SJFSU/vol31_iss4/a128

Keywords:

1,2,3-triazol, fungitsid, click-reaksiya, mis(I) katalizator, azid-alkin qo‘shilishi.

Abstract

Мaqolada 1,2,3-triazol hosilalarining sintezi uchun samarali, selektiv va ekologik toza bo‘lgan “click” kimyoviy yondashuv qo‘llanildi. Reaksiya mis(I) katalizatori ishtirokida alkinlar va organik azidlar o‘rtasida olib borildi. Natijada yuqori unum bilan 2,4-almashingan 1,2,3-triazollar sintez qilindi. Mazkur triazol hosilalari tarkibidagi funksional guruhlar ularga potensial biologik faollik, xususan fungitsid (zamburug‘larga qarshi) xususiyatlar beradi. Olingan birikmalarning fungitsid faolligi in vitro sharoitda dastlabki biologik sinovlar asosida baholandi. Sinov natijalari ushbu sintezlangan triazol hosilalarining yuqori antifungal samaradorlikka ega ekanligini ko‘rsatdi. Ushbu tadqiqot 1,2,3-triazollarni biologik faol moddalar sifatida amaliyotga tadbiq etish borasida istiqbolli yo‘nalishlarni ochib beradi.

Author Biographies

Razakovna, Toshkent davlat stomatologiya instituti

Toshkent davlat stomatologiya instituti, katta o’qituvchi
Asror qizi, Toshkent davlat stomatologiya instituti

Toshkent davlat stomatologiya instituti, k.f.n., assistent (PhD)

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