ACHILLEA MELLIFOLIUM L. O‘SIMLIGINING FITOKIMYOVIY TARKIBI VA XALQ TABOBATIDA QO‘LLANILISHI

Iqbol Tugizova

Scientific information

No. 2 (2025): FarDU ilmiy xabarlari jurnali (Tabiiy fanlar)

PHYTOCHEMICAL COMPOSITION AND USE OF ACHILLEA MILLEFOLIUM IN TRADITIONAL MEDICINE

Iqbol Tugizova^▸^▾

PDF (Uzbek)

Submitted: February 14, 2025
Published: 2025-04-25

Abstract

This review article focuses on the phytochemical composition and traditional medicinal uses of Achillea millefolium. The chemical composition of the plant has been found to contain biologically active compounds such as flavonoids, alkaloids, essential oils, tannins, coumarins, and sesquiterpenes. These compounds make A. millefolium a valuable medicinal plant with anti-inflammatory, analgesic, antibacterial, antifungal, and antioxidant properties. The article provides detailed information on its use in traditional medicine, including stopping bleeding, addressing gastrointestinal issues, alleviating nervous system disorders, and treating respiratory diseases. The data highlight the medicinal importance of A. millefolium and emphasize the need for further research and clinical trials to develop new therapeutic strategies.

References

Pratov O.P., Nabiyev. M.M. 2007 O‘zbekiston yuksak o‘simliklarining zamonaviy tizimi. Toshkent . O‗qituvchi- 2007. 31-32
Shah R., Patel A., Shah M., Peethambaran B. 2015 Anti-acene activity of Achillea ‘Moonshine’ petroleum ether. Journal of medicinal plants Research, 2015; 9(27):755-763.
Grytsyk A. R., Nieko O. V., Melnyk M. V. 2016 Morphological-anatomical study of Achillea L.Species in western region Ukraine. Pharma Innovation, 2016;5(1):71-73.
Koyuncu O. 2020 Morphology, Anatomy, Palynology and Concery ation status of Achille aketenoglui H. Duma. Bangladesh J.Bot, 2020; 49(3):633-641.
Флора Узбекистана, тт. I—VI. — Т.: Фан, 1941 — 1962
Mostafa Farajpour and Mohsen Ebrahimi 2017 Phytochemical and Yield Variation among Iranian Achillea millefolium Accessions
Mustafa K. H., Khorshidi J., Vafaee Y., Rastegar A., Morshedloo M.R., Hossaini, S. 2024. Phytochemical profile and antifungal activity of essential oils obtained from different Mentha longifolia L. accessions growing wild in Iran and Iraq. BMC Plant Biology, 24(1), 461.
Tripon R., Huiban F., Sokolovič M., Bojan L., Camen D., Tulcan C. 2024. Phytochemical, antioxidant and antibacterial profile of Achillea millefolium L. a literature review. JOURNAL of Horticulture, Forestry and Biotechnology, 28(2), 340-348.Jbgyfutu
Akbar S., Akbar S. 2020. Achillea millefolium L.(Asteraceae/Compositae). Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications, 57-67.
Vitalini S., Beretta G, Iriti M., Orsenigo S., Basilico N., 2011. Dall'Acqua S, Iorizzi M, Fico G. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochimica Polonica. 2011;58(2):203-19.
Innocenti G., Vegeto E., Dall’Acqua S., Ciana P., Giorgetti M., Agradi E., Sozzi A., Fico G., Tomè F. 2007 In vitro estrogenic activity of Achillea millefolium L. Phytomedicine. 2007 Feb 19;14(2-3):147-52.
Dalili A., Ebrahimnia Milani S., Kamali N., Mohammadi S., Pakbaz M., Jamalnia S., Sadeghi M. 2022 Beneficial effects of Achillea millefolium on skin injuries; a literature review. Journal of Essential Oil Research. 2022 Nov 2;34(6):479-89.
Apel L., Lorenz P., Urban S., Sauer S., Spring O., Stintzing F.C., Kammerer D.R. 2021. Phytochemical characterization of different yarrow species (Achillea sp.) and investigations into their antimicrobial activity. Zeitschrift für Naturforschung C, 76(1-2), 55-65.
Ahmadi-Dastgerdi, A., Ezzatpanah H., Asgary S., Dokhani S., Rahimi E. 2017. Phytochemical, Antioxidant and Antimicrobial Activity of the Essential Oil from Flowers and Leaves of Achillea millefolium subsp. millefolium. Journal of Essential Oil Bearing Plants, 20(2), 395–409
Pulaj B, Mustafa B, Hajdari A. Differentiation of Achillea millefolium, A. crithmifolia, and A. nobilis through Analysis of Volatile Constituents using HS-SPME-GC/MS and Chemometric Techniques. Records of Natural Products. 2024 Nov 1;18(6).
Ali S.I., Gopalakrishnan B., Venkatesalu V. 2017. Pharmacognosy, phytochemistry, and pharmacological properties of Achillea millefolium L. A review. Phytotherapy Research, 31(7), 1032–1053;
Li H., Xu N., Li J., Aisa H. A. 2023. Guaianolide-type sesquiterpene lactones from Achillea millefolium L. and their anti-inflammatory activity. Phytochemistry, 216, 113894;
Adil M., Dastagir G., Quddoos A., Naseer M., Filimban F.Z. 2024. HPLC analysis, genotoxic and antioxidant potential of Achillea millefolium L. and Chaerophyllum villosum Wall ex. Dc. BMC Complementary Medicine and Therapies, 24(1), 91.
Ijaz F., Nawaz H., Hanif M.A, Ferreira P.M. 2020. Yarrow. In Medicinal Plants of South Asia (pp. 685-697). Elsevier
Abdi M., Adib-Hajbaghery M., Sharif MR. Effect of Achillea millefolium distillate on recovery time in patients with gastroenteritis. Nurs Midwifery Stud. 2016;5(4):e37268. doi: 10.17795/nmsjournal37268.
Baggio C.H., Freitas C.S., Nhaducue P.F., Rieck L., Marques M.C.A. 2002. Action of crude aqueous extract of leaves of Achillea millefolium L.(Compositae) on gastrointestinal tract. Revista Brasileira de Farmacognosia, 12, 31-33.
Yaşar B., Bekdaş M., Düzcü S. E., Çetinkaya A., Alışık M., Yıldırım A.B., Bekdaş M.F. 2024. Effects of Yarrow (Achillea millefolium) Extract on Acute Lung Injury: An Experimental Study.
Arias-Durán L., Estrada-Soto S., Hernández-Morales M., Millán-Pacheco C., Navarrete-Vázquez G., Villalobos-Molina R., Almanza-Pérez J.C. 2021. Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies. Journal of Ethnopharmacology, 273, 113948.
Jenabi E., Fereidoony B. 2015. Effect of Achillea millefolium on relief of primary dysmenorrhea: a double-blind randomized clinical trial. Journal of pediatric and adolescent gynecology, 28(5), 402-404.
Belsito D.V., Klaassen C.D., Liebler D.C., Hill R.A. 2013. Amended Safety Assessment of Achillea Millefolium-Derived Ingredients as Used in Cosmetics.
Becker L.C., Bergfeld W.F., Belsito D.V., Hill R A., Klaassen C.D., Liebler D.C., Andersen F.A. 2016. Safety assessment of Achillea millefolium as used in cosmetics. International journal of toxicology, 35(3_suppl), 5S-15S. doi: 10.21273/HORTSCI11654-16
Altınok-Yipel F., Tekeli İ.O., Özsoy Ş.Y., Güvenç M., Kaya A., Yipel M. 2019. Hepatoprotective activity of linalool in rats against liver injury induced by carbon tetrachloride. International journal for vitamin and nutrition research.
Van Wyk BE., Wink M. Medicinal plants of the world. Cabi; 2018 Oct 31.
Gaweł-Bęben K., Strzępek-Gomółka M., Czop M., Sakipova Z., Głowniak K., Kukula-Koch W. 2020. Achillea millefolium L. and Achillea biebersteinii Afan. hydroglycolic extracts–bioactive ingredients for cosmetic use. Molecules, 25(15), 3368.

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[1] Pratov O.P., Nabiyev. M.M. 2007 O‘zbekiston yuksak o‘simliklarining zamonaviy tizimi. Toshkent . O‗qituvchi- 2007. 31-32

[2] Shah R., Patel A., Shah M., Peethambaran B. 2015 Anti-acene activity of Achillea ‘Moonshine’ petroleum ether. Journal of medicinal plants Research, 2015; 9(27):755-763.

[3] Grytsyk A. R., Nieko O. V., Melnyk M. V. 2016 Morphological-anatomical study of Achillea L.Species in western region Ukraine. Pharma Innovation, 2016;5(1):71-73.

[4] Koyuncu O. 2020 Morphology, Anatomy, Palynology and Concery ation status of Achille aketenoglui H. Duma. Bangladesh J.Bot, 2020; 49(3):633-641.

[5] Флора Узбекистана, тт. I—VI. — Т.: Фан, 1941 — 1962

[6] Mostafa Farajpour and Mohsen Ebrahimi 2017 Phytochemical and Yield Variation among Iranian Achillea millefolium Accessions

[7] Mustafa K. H., Khorshidi J., Vafaee Y., Rastegar A., Morshedloo M.R., Hossaini, S. 2024. Phytochemical profile and antifungal activity of essential oils obtained from different Mentha longifolia L. accessions growing wild in Iran and Iraq. BMC Plant Biology, 24(1), 461.

[8] Tripon R., Huiban F., Sokolovič M., Bojan L., Camen D., Tulcan C. 2024. Phytochemical, antioxidant and antibacterial profile of Achillea millefolium L. a literature review. JOURNAL of Horticulture, Forestry and Biotechnology, 28(2), 340-348.Jbgyfutu

[9] Akbar S., Akbar S. 2020. Achillea millefolium L.(Asteraceae/Compositae). Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications, 57-67.

[10] Vitalini S., Beretta G, Iriti M., Orsenigo S., Basilico N., 2011. Dall'Acqua S, Iorizzi M, Fico G. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochimica Polonica. 2011;58(2):203-19.

[11] Innocenti G., Vegeto E., Dall’Acqua S., Ciana P., Giorgetti M., Agradi E., Sozzi A., Fico G., Tomè F. 2007 In vitro estrogenic activity of Achillea millefolium L. Phytomedicine. 2007 Feb 19;14(2-3):147-52.

[12] Dalili A., Ebrahimnia Milani S., Kamali N., Mohammadi S., Pakbaz M., Jamalnia S., Sadeghi M. 2022 Beneficial effects of Achillea millefolium on skin injuries; a literature review. Journal of Essential Oil Research. 2022 Nov 2;34(6):479-89.

[13] Apel L., Lorenz P., Urban S., Sauer S., Spring O., Stintzing F.C., Kammerer D.R. 2021. Phytochemical characterization of different yarrow species (Achillea sp.) and investigations into their antimicrobial activity. Zeitschrift für Naturforschung C, 76(1-2), 55-65.

[14] Ahmadi-Dastgerdi, A., Ezzatpanah H., Asgary S., Dokhani S., Rahimi E. 2017. Phytochemical, Antioxidant and Antimicrobial Activity of the Essential Oil from Flowers and Leaves of Achillea millefolium subsp. millefolium. Journal of Essential Oil Bearing Plants, 20(2), 395–409

[15] Pulaj B, Mustafa B, Hajdari A. Differentiation of Achillea millefolium, A. crithmifolia, and A. nobilis through Analysis of Volatile Constituents using HS-SPME-GC/MS and Chemometric Techniques. Records of Natural Products. 2024 Nov 1;18(6).

[16] Ali S.I., Gopalakrishnan B., Venkatesalu V. 2017. Pharmacognosy, phytochemistry, and pharmacological properties of Achillea millefolium L. A review. Phytotherapy Research, 31(7), 1032–1053;

[17] Li H., Xu N., Li J., Aisa H. A. 2023. Guaianolide-type sesquiterpene lactones from Achillea millefolium L. and their anti-inflammatory activity. Phytochemistry, 216, 113894;

[18] Adil M., Dastagir G., Quddoos A., Naseer M., Filimban F.Z. 2024. HPLC analysis, genotoxic and antioxidant potential of Achillea millefolium L. and Chaerophyllum villosum Wall ex. Dc. BMC Complementary Medicine and Therapies, 24(1), 91.

[19] Ijaz F., Nawaz H., Hanif M.A, Ferreira P.M. 2020. Yarrow. In Medicinal Plants of South Asia (pp. 685-697). Elsevier

[20] Abdi M., Adib-Hajbaghery M., Sharif MR. Effect of Achillea millefolium distillate on recovery time in patients with gastroenteritis. Nurs Midwifery Stud. 2016;5(4):e37268. doi: 10.17795/nmsjournal37268.

[21] Baggio C.H., Freitas C.S., Nhaducue P.F., Rieck L., Marques M.C.A. 2002. Action of crude aqueous extract of leaves of Achillea millefolium L.(Compositae) on gastrointestinal tract. Revista Brasileira de Farmacognosia, 12, 31-33.

[22] Yaşar B., Bekdaş M., Düzcü S. E., Çetinkaya A., Alışık M., Yıldırım A.B., Bekdaş M.F. 2024. Effects of Yarrow (Achillea millefolium) Extract on Acute Lung Injury: An Experimental Study.

[23] Arias-Durán L., Estrada-Soto S., Hernández-Morales M., Millán-Pacheco C., Navarrete-Vázquez G., Villalobos-Molina R., Almanza-Pérez J.C. 2021. Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies. Journal of Ethnopharmacology, 273, 113948.

[24] Jenabi E., Fereidoony B. 2015. Effect of Achillea millefolium on relief of primary dysmenorrhea: a double-blind randomized clinical trial. Journal of pediatric and adolescent gynecology, 28(5), 402-404.

[25] Belsito D.V., Klaassen C.D., Liebler D.C., Hill R.A. 2013. Amended Safety Assessment of Achillea Millefolium-Derived Ingredients as Used in Cosmetics.

[26] Becker L.C., Bergfeld W.F., Belsito D.V., Hill R A., Klaassen C.D., Liebler D.C., Andersen F.A. 2016. Safety assessment of Achillea millefolium as used in cosmetics. International journal of toxicology, 35(3_suppl), 5S-15S. doi: 10.21273/HORTSCI11654-16

[27] Altınok-Yipel F., Tekeli İ.O., Özsoy Ş.Y., Güvenç M., Kaya A., Yipel M. 2019. Hepatoprotective activity of linalool in rats against liver injury induced by carbon tetrachloride. International journal for vitamin and nutrition research.

[28] Van Wyk BE., Wink M. Medicinal plants of the world. Cabi; 2018 Oct 31.

[29] Gaweł-Bęben K., Strzępek-Gomółka M., Czop M., Sakipova Z., Głowniak K., Kukula-Koch W. 2020. Achillea millefolium L. and Achillea biebersteinii Afan. hydroglycolic extracts–bioactive ingredients for cosmetic use. Molecules, 25(15), 3368.