BETULIN KISLOTASINING ENERGETIK VA GEOMETRIK PARAMETRLARINI EKSPERIMENTAL O‘RGANISH

Turg‘unboyev Shavkatjon Shuhratjon o‘g‘li

doi:10.56292/SJFSU/vol31_iss5/a109

BETULIN KISLOTASINING ENERGETIK VA GEOMETRIK PARAMETRLARINI EKSPERIMENTAL O‘RGANISH

Mualliflar

Turg‘unboyev Shavkatjon Shuhratjon o‘g‘li

Farg‘ona davlat universiteti

https://orcid.org/0009-0006-7998-5368

DOI:

https://doi.org/10.56292/SJFSU/vol31_iss5/a109

Kalit so‘zlar:

betulin kislotasi, energetik parametrlar, Avogadro, HyperChem, DFT, molekulyar docking, molekulyar dinamika.

Annotatsiya

Ushbu maqolada betulin kislotasining geometrik va energetik parametrlarini o‘rganish natijalari yoritilgan. Tadqiqotlarda Avogadro, HyperChem va ChemOffice dasturlaridan, shuningdek DFT, MD, QSAR va molekulyar docking kabi zamonaviy yondashuvlardan foydalanigan. Hisoblashlar natijasi sifatida hosil bo‘lish energiyalari, bog‘ uzunliklari, elektron tuzilish parametrlarining farqlanishi va molekulyar barqarorlik darajalari aniqlangan. Olingan natijalar betulin kislotasining farmatsevtika va nanomateriallarda qo‘llanish istiqbollarini yoritib beradi.

Muallif haqida

Turg‘unboyev Shavkatjon Shuhratjon o‘g‘li, Farg‘ona davlat universiteti

Farg‘ona davlat universiteti, k.f.b.f.d., (PhD), dotsent

Adabiyotlar

1. Yu, P., Cao, W., & Wang, Y. (2024). Dynamics simulation and in vitro studies of betulinic acid derivative with liver X receptor. Journal of Biomolecular Structure and Dynamics, 42(13), 7014–7023. https://doi.org/10.1080/07391102.2023.2239924

2. Chen, S., Lin, B., Gu, J., et al. (2022). Binding interaction of betulinic acid to α-glucosidase and its allevia-tion on postprandial hyperglycemia. Molecules, 27(8), 2517. https://doi.org/10.3390/molecules27082517

3. Salau, V. F., Erukainure, O. L., Aljoundi, A., et al. (2024). Exploring the inhibitory action of betulinic acid on key digestive enzymes linked to diabetes via in vitro and computational models: Approaches to anti-diabetic mecha-nisms. SAR and QSAR in Environmental Research, 35(5), 411–432. https://doi.org/10.1080/1062936X.2024.2352729

4. Poorsargol, M., & Setayesh-Mehr, Z. (2022). Betulinic acid and 3-O-acetyl-betulinic acid interactions with external and internal surface of boron-nitride nanotubes: A DFT and MD investigation. Computational and Theoretical Chemistry, 1213, 113738. https://doi.org/10.1016/j.comptc.2022.113738

5. Dangroo, N. A., Moussa, Z., Alluhaibi, M. S., et al. (2025). Novel C-3 and C-20 derived analogs of betulinic acid as potent cytotoxic agents: Design, synthesis, in vitro and in silico studies. RSC Advances, 15, 15164–15177. https://doi.org/10.1039/D5RA01038A

Yuklab olishlar

Nashr etilgan

2026-01-27

Son

№ 5 (2025): FarDu ilmiy xabarlar jurnali (TABIIY FANLAR)

Bo‘lim

Chemistry

Litsenziya

Ushbu ish Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Xalqaro litsenziyasi ostida litsenziyalangan.

Qanday iqtibos keltirish

BETULIN KISLOTASINING ENERGETIK VA GEOMETRIK PARAMETRLARINI EKSPERIMENTAL O‘RGANISH. (2026). Scientific Journal of the Fergana State University, 31(5), 109. https://doi.org/10.56292/SJFSU/vol31_iss5/a109