COMPARATIVE EFFECT OF “AS LUPINUS” AND GLYCORAZMULIN ON THE HIGH-CONDUCTANCE PORE OF RAT LIVER MITOCHONDRIA UNDER ALLOXAN-INDUCED DIABETES CONDITIONS
DOI:
https://doi.org/10.56292/SJFSU/vol31_iss6/a286Keywords:
Japanese sophora (Sophora japonica L), lupin (Lupinus angustifolius L), glucose, insulin, MDA, mPTP, mitoKATF, LPO, Alloksan («Lachema» «Chemapol» Chexiya), EGTA, EDTA, KH2PO4, K2HPO4, Hepes, KCl, MgSO4, suksinat, oligomitsin, rotenon, ATF («Serva», Germaniya).Abstract
This study investigated the antioxidant activity of a mixture of Japanese (Sophora japonica L), which grows in Uzbekistan, and lupin (Lupinus angustifolius L). It was found that a 1:1 ratio of the mixture exhibits high antioxidant activity. Based on this 1:1 mixture, a biologically active food supplement for the treatment of diabetes was developed, named “As Lupinus.” To analyze the biological activity of the “As Lupinus” supplement under alloxan-induced diabetic conditions, a comparative study of its effects and those of glycorasmulin on the high-permeability pore of rat liver mitochondria was conducted in vivo at the Tashkent Institute of Bioorganic Chemistry. The aim of the study is to conduct preclinical investigations of the biological activity of the “As Lupinus” supplement and to develop antidiabetic food supplements for diabetes treatment and their practical application.
References
1. Агзамов Х., Алматов К.Т., Рахимов М.М., Туракулов Я.Х. Функционирование митохондрий печени при аллоксановам диабете // Вопросы мед. химии. –1983. - Т.29. – №1.– С. 61-65.
2. Асраров М.И., Позилов М.К., Эргашев Н.А., Рахматуллаева М.М. Влияние гипогликемического средства гликоразмулина на функциональное состояние митохондрий при стрептозотоцин¬индуцированном диабете // Проблемы эндокринология – 2014 – Т.60 (№3) – С. 38-42.
3. Meyts P.D. Insulin and its receptor: Structure, function and evolution // BioEssays – 2004: – V. 26(12): – P. 1351-1362
4. Асқаров.И.Р. Табобат қомуси . Тошкент.- Мумтоз сўз. - 2019.
5. Асқаров И.Р. Товарлар кимёси (Монография). Фан ва технологиялар Марказининг босмахонаси. -Тошкент - 2019. -1000 б.
6. Mamatqulova, S. A., & Abdujabborova, C. S. qizi. (2024). Lyupin oʻsimligi kimyoviy tarkibi va xalq tabobatida qoʻllanilishi. Educational research in universal sciences, 3(3), 73–79.
7. Asqarov, I., Mamatqulova , S., & Abdujabborova , C. (2024). "AS LUPINUS" tarkibidagi oqsillar miqdorini aniqlash. Universal Xalqaro Ilmiy Jurnal, 1(3), 22–29. Retrieved from.https://universaljurnal.uz/index.php/jurnal/article/view/632
8. Abdujabborova Ch. S., I.R.Asqarov, S.A.Mamatqulova - // Yapon saforasi va lupin o‘simliklarining aralashmasi tarkibidagi aminokislotalar miqdorini aniqlash // Qo‘qon DPI. Ilmiy xabarlar // -2024
9. Abdujabborova Ch. S., I.R.Asqarov, S.A.Mamatqulova - // Yapon saforasi va lupin o‘simliklarining aralashmasi tarkibidagi flavonoidlar miqdorini aniqlash // Qo‘qon DPI. Ilmiy xabarlar // -2024
10. Аскаров, И. Р., Маматкулова, С. А., & Абдужабборова, Ч. С. к. (2024). Анализ химических элементов софоры японской. Журнал химии товаров и народной медицины, 3(1), 97–111.
11. Аскаров, И. Р., Маматкулова, С. А., & Абдужабборова, Ч. С. к. (2024). Определение антиоксидантной активности веществ, содержащихся в смеси японского сафлорового дерева и люпина. Журнал химии товаров и народной медицины, 3(1), 192–204. https://doi.org/10.55475/jcgtm/vol3.iss1.2024.259.
12. Абдужабборова Чаросхон Санжарбек кизи. (2024). ОПРЕДЕЛЕНИЕ ОСТРОЙ ТОКСИЧНОСТИ "AS LUPINUS". Universal International Scientific Journal, 1(9), 151–157. Https://doi.org/10.5281/zenodo.14554711
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Scientific journal of the Fergana State University
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
