STREPTOMYCES SPECTABILIS FERMENTATSIYASIDA MUHIT SHAROITLARINI AHAMIYATI

Abdunazarov No‘monjon Sultonnazar o‘g‘li; Mamarasulov Bahodir Dolixonovich

doi:10.56292/SJFSU/vol31_iss5/a136

Authors

Abdunazarov No‘monjon Sultonnazar o‘g‘li

O‘zbekiston Respublikasi Fanlar Akademiyasi, Mikrobiologiya instituti

https://orcid.org/0009-0006-7139-271X
Mamarasulov Bahodir Dolixonovich

O‘zbekiston Respublikasi Fanlar Akademiyasi Mikrobiologiya instituti

https://orcid.org/0000-0003-0455-8928

DOI:

https://doi.org/10.56292/SJFSU/vol31_iss5/a136

Keywords:

Streptomyces spectabilis, fermentation, secondary metabolites, ISP media, nutrient composition

Abstract

To enhance the prоductiоn of biologically active compounds by the Streptomyces spectabilis strain, cultivation conditions were optimized, and the strain’s morphological chаracteristics were examined microscopically across various ISP (International Streptomyces Project) nutrient media. Streptomyces spectabilis is a microorganism known for producing multiple antibiotics and holds significant importance in medicine and the pharmaceutical industry.

Author Biographies

Abdunazarov No‘monjon Sultonnazar o‘g‘li, O‘zbekiston Respublikasi Fanlar Akademiyasi, Mikrobiologiya instituti

O‘zbekiston Respublikasi Fanlar Akademiyasi, Mikrobiologiya instituti ikkinchi bosqich tayanch doktoranti
Mamarasulov Bahodir Dolixonovich, O‘zbekiston Respublikasi Fanlar Akademiyasi Mikrobiologiya instituti

O‘zbekiston Respublikasi Fanlar Akademiyasi Mikrobiologiya instituti katta ilmiy xodimi

References

1. Lajtai-Szabó P. et al. The role of physical support in secondary metabolite production by Streptomyces spe-cies //Biochemical Engineering Journal. 2022.Т 185. – С. 108495.

2. Suliman M., Bishr A. S., Aboshanab K. M. Deciphering hygromycin B biosynthetic pathway and D-optimal de-sign for production optimization //World Journal of Microbiology and Biotechnology.2025. – Т. 41. – №. 5. – С. 1-14.

3. George, Maya, and Gerard D. Wright. “Revisiting the potential of natural products in antimycobacterial thera-py: advances in drug discovery and semisynthetic solutions.” Current Opinion in Microbiology 83 (2025): 102576.

4. Streptomyces spectabilis shtammning ikkilamchi metabolitlarini kimyoviy tuzilishi va biologik faolliklari. Na-mangan: O‘zbekiston 2024

5. Suliman, Muath, Amr S. Bishr, and Khaled M. Aboshanab. “Deciphering hygromycin B biosynthetic pathway and D-optimal design for production optimization.” World Journal of Microbiology and Biotechnology 41.5 (2025): 1-14.

6. Magar, Rubin Thapa, and Jae Kyung Sohng. “Natural products with γ-pyrone scaffold from Streptomyces.” Applied Microbiology and Biotechnology 108.1 (2024):

7. Selvaraj, Jeraldin Nisha, et al. “Statistical optimization of media components for antibiotic production in Strep-tomyces sp.” Electronic Journal of Biotechnology 65 (2023): 1-13.

8. Lertcanawanichakul, Monthon, and Tuanhawanti Sahabuddeen. “Characterization of Streptomyces sp. KB1 and its cultural optimization for bioactive compounds production." PeerJ 11 (2023): e14909.

9. Sun, Yuchen, et al. "Isolation, identification and molecular mechanism analysis of the nematicidal compound spectinabilin from newly isolated Streptomyces sp. 2023

10. Abdunazarov.N,S. Streptomyces spectabilis shtammining antibiotikka chidamli bakteriyalarga qarshi faol-ligini baholash. Namangan: O‘zbekiston 2024