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Biology

No. 1 (2023): Scientific journal of the Fergana State University (Exact and natural sciences)

GENETIC ASPECTS OF REACTIVE ARTHRITIS

Submitted
June 27, 2023
Published
2023-07-05

Abstract

Reactive arthritis is one of the most common chronic inflammatory diseases of the joints. Patients with reactive arthritis make up about 10% of patients in rheumatological hospitals, and in the chronic form of the disease, a significant loss of the functional abilities of the joints and the occurrence of severe complications can develop, which leads to disability of patients. Interest in reactive arthritis is also associated with the fact that a number of patients, especially when the process is chronic, develop destructive processes in the joints up to ankylosing. The development of destruction of the joints and spine in patients with reactive arthritis, in turn, adversely affects the quality of life of patients, especially in young people, as well as a decrease in their ability to work and an increase in morbidity remain an urgent problem.

References

  1. Аннунциато Ф., Косми Л., Лиотта Ф. и др. Т хелперные клетки типа 17 происхождение, особенности и возможная роль при ревматических заболеваниях.: Nat Rev Rheumatol, 2009; 5. – стр. 325–331.
  2. Корн Т., Беттелли Э., Оукка М. и др. IL-17 и клетки Th17. Annu Rev Immunol, 2009; 27. -Стр. 485–517.
  3. Лила А.М., Гапонова Т.В. Реактивные артриты: особенности патогенеза и терапевтическая тактика. РМЖ, 2010;27. – стр. 1663.
  4. Понасенко А.В., Цепокина А.В., Хуторная М.В., Долгих В.А., Малышев И.Ю., Барбараш О.Л.. Полиморфизм генов ИЛ 18 rap и ИЛ 18 r1 ассоциирован с рисками развития инфаркта миокарда у пациентов со стабильной формой ишемической болезни сердца. Трансляционная медицина, 2018.Tом 5 №4. – стр. 125–131.
  5. Шэнь Л., Чжан Х., Ян Т. и др. Связь между полиморфизмом интерлейкина 17A и предрасположенностью к ревматоидному артриту у населения Китая. Джин 2015; 566 18–22.
  6. Якушенко Е.В. Интерлейкин-18: биологические эффекты и перспективы клинического применения: автореф. дис. д-ра мед. наук 14.03.09 / Якушенко Е.В. – Новосибирск, 2012.
  7. Якушенко Е.В., Лопатникова Ю.А., Сенников С.В. Интерлейкин-18 и его роль в иммунном ответе. Медицинская Иммунология 2005, Т.7, No 4, стр 355-364.
  8. Abduraxmanova N. M. B., Axmedov X. S. Reactive arthritis-a modern view of the problem //Журнал биомедицины и практики. – 2021. – T. 6. – №. 1.
  9. Abdurakhmanova N. M. et al. MODERN METHODS OF TREATMENT OF PATIENTS WITH ANKYLOSING SPONDYLITIS //International Journal of Advance Scientific Research. – 2022. – Т. 2. – №. 11. – С. 112-118.
  10. Chen P, Li Y, Li L, Zhang G, Zhang F, Tang Y, Zhou L, Yang Y, Li J. Association between the interleukin (IL)-17A rs2275913 polymorphism and rheumatoid arthritis susceptibility: a meta-analysis and trial sequential analysis. J Int Med Res. 2021 Oct; 49(10):3000605211053233. doi: 10.1177/03000605211053233. PMID: 34704484; PMCID: PMC8554571.
  11. Cohen Susanne E., Bodmer Hellen C. Cytotoxic T lymphocytes recognize and lyse chondrocytes under inflammatory, but not non–inflammatory conditions. Immunology 2003; 109:8–14.
  12. Colbert R.A. HLA–B27 misfolding: a solution to the spondyloarthropathy conudrum? Mol Med Today 2000;6:224–230.
  13. Hammer M., Nettelnbreker E., Hopf S., Schmitz E., Porshke K., Zeidler H. Chlamidial rRNA in the joints of patients with Chlamydia–induced arthritis and undifferentiated arthritis. Clin Exp Rheumatol 1992;10:63–66.
  14. J. R. Vidal-Castiñeira, A. López-Vázquez, R. Diaz-Peña et al., “A single nucleotide polymorphism in the IL17ra promoter is associated with functional severity of ankylosing spondylitis,” PLoS One, vol. 11, no. 7, article e0158905, 2016.
  15. Khalmetova F. I., Akhmedov K.S., Razakova F.S. Comparative Analysis of the Clinical Presentation of Reactive Arthritis // American Journal of Medicine and Medical Sciences. – 2021. –Vol. 11(1). 75-78.
  16. Khalmetova F. I., Akhmedov K.S., Buranova S.N. The role of imaging techniques in the assessment of structural changes in the joint in reactive arthritis - Academicia Globe: Inderscience Research, 2022
  17. Marco A. Rocha Loures, Luciana C. Macedo, Denise M. Reis, Camila F. Oliveira, Jean L. Meneguetti, Gabriela F. Martines, Janisleya S. F. Neves, Eliana de Souza, Ana M. Sell, Jeane E. L. Visentainer, "Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population", Mediators of Inflammation, vol. 2018, Article ID 1395823, 7 pages, 2018.
  18. Schumaher H.R. Jr, Arayssi T., Crane M., et al. Chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects. Arthritis Rheum 1999;42:1281–1284.
  19. Sibilia J., Libmach F–X. Reactive arthritis or chronic infectious arthritis? Ann Rheum Dis 2002;61:580–587.
  20. Sobao Y., Tsuchiya N., Takiguchi M., et al. Overlapping peptide– binding specificities of HLA–B27 and B39. Arthritis Rheum 1999;42:175–181.
  21. Mirrakhimova M.K. Improving methods of treatment of atopic pathology in children //Journal of Critical Reviews.-№12.-р. 190-192
  22. Mirrakhimova M.H., Nishanbaeva N.Y., Clinical Manifestations Of Connective Tissue Dysplasia In Children With Glomerulonephritis //Journal of Pharmaceutical Negative Results/Volume 13/Special Issue 9 ¦ 2022,rr.4203-4205.
  23. Nishanbayeva N.Yu., Mirraximova M.X. Bolalarda atopik dermatitda oshqozon ichak traktidagi klinik laborator o‘zgarishlarni aniqlash, tashxislash va davolash tamoyillarini takomillashtirish //«Tibbiyotda yangi kun» 6(38/1)2021 ISSN 2181-712X. EISSN 2181-2187 pp.720-726.