METHOD FOR SYNTHESIS OF M-TOLIL-4-METILFENOKSIASETAT BASED ON M-TOLYL CHLORACETATE
Keywords:
m-cresol, 4-methylphenol, biological activity, antibacterial, analgesic microorganism, bactericidal, chloracetylation, catalysts, mechanism, extraction, solvent, dielectric constants, synthesis.Abstract
In this research work, m-cresol was reacted with chloroacetyl chloride under different conditions. When m-cresol is reacted with chloroacetyl chloride in the presence of catalytic amounts of FeCl3, FeCl3×6H2O, ZnCl2, Fe2(SO4)3 and TAA, it was found that a mixture of isomers is formed. When research was continued with the aim of synthesizing an individual substance, a method of synthesizing m-tolylchloroacetate in a benzene solution was found. The reaction mechanism of this reaction was developed and theoretically justified. Nucleophilic exchange reaction of m-Tolylchloroacetate with 4-methylphenol was carried out in benzene, acetone, dioxane, DMF, DMSO solutions. The yield of the reaction was high in DMSO solution, and the yield of m-tolyl-4-methylphenoxyacetate was 95%.
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