БЕТУЛОН КИСЛОТАСИНИ СИНТЕЗ ҚИЛИШ

Ш.Ш.Турғунбоев; А.Х.Хаитбаев

Chemistry

No. 4 (2019): Scientific journal of the Fergana state university

SYNTHESIS OF THE BETULINIC ACID

Ш.Ш.Турғунбоев^▸^▾
А.Х.Хаитбаев^▸^▾

PDF (Uzbek)

Submitted: June 22, 2023
Published: 2023-06-24

Abstract

Today, one of the most important tasks for the further development of the pharmaceutical industry is medicines obtained from local raw materials. This article describes the production of betulin from the bark of the Betula pendula tree growing on the territory of Uzbekistan, the synthesis of various derivatives based on it, and the study of the structure of substances by physical methods. Based on these studies, medicines will be created from local raw materials.

References

Tolstikov G.A., Flehter O.B., Sнults E.E., Baltina L.A., Tolstikov A.G. Betulin i yego proizvodniye. Ximiya I biologicheskaya aktivnost. Himiya v interesah ustoychivogo razvitiya. 13. 2005. S 1-30. 2. Kuznetsov B.N., Levdanskiy V.A., Yeskin A.P., Polejayeva N.I. Videleniye betulina i suberina iz kori beryozi, aktivirovannoy v usloviyah “vzrivnogo avtogidroliza”. Himiya rastitelnogo sir’ya. 1998. № 1. S 5-9. 3. Zuco, V., Supino, R., Righetti, S. C., Cleris, L., Marchesi, E.; Gambacorti-Passerini, C., Formelli, F. Selective cytotoxicity of betulinic acid tumor cell lines, but not on normal cells.Cancer Lett. 2002, 175. 4. Pisha E.; Chai H.; Lee I.S.; Chagwedera T.E.; Farnsworth N.R.; Cordell G.A.; Beecher C.W.; Fong H.H.; Kinghorn A.D.; Brown D.M.; et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of a’o’tosis. Nat. Med.1995, 1. 5. Fulda, S.; Jeremias, I.; Steiner, H. H.; Pietsch, T.; Debatin, K. M. Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells. Int. J. Cancer 1999, 82, 435-441. Int. J. Mol. Sci. 2008, 9

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[1] Tolstikov G.A., Flehter O.B., Sнults E.E., Baltina L.A., Tolstikov A.G. Betulin i yego proizvodniye. Ximiya I biologicheskaya aktivnost. Himiya v interesah ustoychivogo razvitiya. 13. 2005. S 1-30. 2. Kuznetsov B.N., Levdanskiy V.A., Yeskin A.P., Polejayeva N.I. Videleniye betulina i suberina iz kori beryozi, aktivirovannoy v usloviyah “vzrivnogo avtogidroliza”. Himiya rastitelnogo sir’ya. 1998. № 1. S 5-9. 3. Zuco, V., Supino, R., Righetti, S. C., Cleris, L., Marchesi, E.; Gambacorti-Passerini, C., Formelli, F. Selective cytotoxicity of betulinic acid tumor cell lines, but not on normal cells.Cancer Lett. 2002, 175. 4. Pisha E.; Chai H.; Lee I.S.; Chagwedera T.E.; Farnsworth N.R.; Cordell G.A.; Beecher C.W.; Fong H.H.; Kinghorn A.D.; Brown D.M.; et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of a’o’tosis. Nat. Med.1995, 1. 5. Fulda, S.; Jeremias, I.; Steiner, H. H.; Pietsch, T.; Debatin, K. M. Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells. Int. J. Cancer 1999, 82, 435-441. Int. J. Mol. Sci. 2008, 9