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O‘zbekcha

EFFECT OF PLANT ALKALOIDS ON MITOCHONDRIAL MEMBRANE PERMEABILITY

Authors

  • I.Karimov nomidagi Toshkent davlat texnika universiteti
  • Qarshi davlat universiteti

Keywords:

митохондрии, алкалоиды, протопин, проводимость, invitro, среда, ионы кальция.

Abstract

The study of the physicochemical properties of mitochondrial membranes shows that its inner membrane selectively allows certain compounds to pass through, for example, drugs. It is necessary to take into account the influence of pharmacological agents on the functional parameters of mitochondria not only from a toxicological, but also from a therapeutic point of view. Potential targets for several pharmacological agents have been identified at the mitochondrial level.

Author Biographies

  • , I.Karimov nomidagi Toshkent davlat texnika universiteti

    I.Karimov nomidagi Toshkent davlat texnika universiteti, Biotexnologiya kafedrasi professori v.b

  • , Qarshi davlat universiteti

    Qarshi davlat universiteti, Fiziologiya kafedrasi o‘qituvchisi

References

Azzone G.F., Azzi A. Volume changes in liver mitochondria // Proc. Natl. Acad. Science USA. – 1965. – V. 53. – P. 1084 - 1089.

Brierley G.P. Passive permeability and energy-linked ion movements in isolated hearth mitochondria // Ann. N. Y. Acad. Sci. – 1974. – V. 227. – P. 398-411.

Gustafsson Å.B., Gottlieb R.A. Heart mitochondria: gates of life and death // Cardiovascular Research. – 2008. – V. 77. – P. 334-343;

Davidson A.M., Halestrap A.P. Partial inhibition by cyclosporin A of the swelling of liver mitochondria in vivo and in vitro induced by sub-micromolar [Ca2+], but not by butyrate // Biochem. J. – 1990. – V. 268. – P. 147-152.

Dudkina N.V., Sunderhaus S., Boekema E.J., Braun H.P. The higher level of organization of the oxidative phosphorylation system: mitochondrial supercomplexes // J. Bioenerg. Biomembr. – 2008. – V. 40. – P. 419–424.

Fruehauf J.P., Meyskens F.L. Reactive Oxygen Species: A Breath of Life or Death? // Clinical Cancer Research. – 2007. – V. 13. – P. 789-796

Fuentes-Prior P., Salvesen G.S. The protein structures that shape caspase activity, specificity, activation and inhibition // Biochem. J. – 2004. – V. 384. – P. 201–232.

Szewczyk A., Wojtczak L. Mitochondria as a pharmacological target // Pharmacol. Rev. – 2002. – V. 54. – P. 101–127 )

Барам Н.И., Исмаилов А.И. Биологическая активност госсипола и его производных//Химия природных соединений.– Москва, 1993. – №3. – С. 334-49.

Гагелганс А.И. Транспорт ионов в митохондриях и действие тиреоидных гормонов // Дис. канд. биол. наук. – Ташкент. 1970. – С. 177.

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Published

2023-11-28