
The addition of nucleophilic reagents to the carbon atom of a carbonyl group is one of the fundamental reactions and is of considerable interest, since it plays a role in chemical and biochemical processes. The tautomeric equilibrium of an organic reagent characterizes the reactivity of it’s functional groups. An investigation of the reactivity of tautomeric forms of reagents is a necessary stage for the subsequent study of complexation reactions. In addition, determining the effect of substituents on the position of tautomeric equilibrium and effective charges of atoms in reaction centers is an urgent task.
The addition of nucleophilic reagents to the carbon atom of a carbonyl group is one of the fundamental reactions and is of considerable interest, since it plays a role in chemical and biochemical processes. The tautomeric equilibrium of an organic reagent characterizes the reactivity of it’s functional groups. An investigation of the reactivity of tautomeric forms of reagents is a necessary stage for the subsequent study of complexation reactions. In addition, determining the effect of substituents on the position of tautomeric equilibrium and effective charges of atoms in reaction centers is an urgent task.