SURUNKALI PARODONTITDA BIOMARKERLAR KOMBINATSIYASINING KORRELYATSION BOGʻLIQLIGI

Sabogul Rustamova; Abdugafur  Xadjimetov

doi:10.56292/SJFSU/vol31_iss6/a%p

Authors

Rustamova Sаbogul Mamarejabovna

Toshkent davlat tibbiyot universiteti

https://orcid.org/0009-0000-1939-7827
Xadjimetov Abdugafur Axatovich

Toshkent Davlat tibbiyot universiteti

https://orcid.org/0000-0002-0143-9563

DOI:

https://doi.org/10.56292/SJFSU/vol31_iss6/a%25p

Keywords:

Surunkali tarqalgan parodontit, gingivit, ogʻiz suyuqligi, periodont, biomarkerlar, metalloproteazalar, korrelyatsiya.

Abstract

Ogʻiz suyuqligi qon kabi, tananing axborot beruvchi materialidir. Ushbu biologik suyuqlik ogʻiz boʻshligʻi organlari gomeostazini ta'minlovchi omillaridan biri boʻlib, uning hususiyatlarini oʻrganish nafaqat stomatologlar, balki onkologiya, gastroenterologiya, ginekologiya, kardiologiya va boshqa soha mutaxassislari uchun ham qiziqish uygʻotadi. Ilmiy tadqiqot davomida qonning laborator diagnostik usullaridan birmuncha afzalliklarga ega bo’lgan ogʻiz suyuqligining klinik va biokimyoviy koʻrsatkichlarini baholash orqali gingivit va surunkali tarqalgan parodontit kasalligining ogʻirlik holati, erta tashxislash va davolash samaradorligi aniqlandi. Ogʻiz suyuqligining oʻzgarish darajasidan biomaterial sifatida foydalanish faqat kasallikni erta tashxislash, uning ogʻirlik darajasini belgilashda foydalanibgina qolmasdan, kasallik bilan kurashayotgan bemorlarda parodont toʻqimalarda kechayotgan oʻzgarishlar bosqichini aniqlashda va kasallikning oldini oluvchi salivadiagnostikaga qaratilgan ilmiy tadqiqotlarda keng qoʻllanilishi mumkin.

Author Biographies

Rustamova Sаbogul Mamarejabovna, Toshkent davlat tibbiyot universiteti

Toshkent Davlat tibbiyot universiteti, biologiya fanlari boʻyicha falsafa doktori, PhD
Xadjimetov Abdugafur Axatovich, Toshkent Davlat tibbiyot universiteti

Toshkent Davlat tibbiyot universiteti, biologiya fanlari doktori, professor

References

1. Kurgan, S., & Kantarci, A. (2022). Salivary metabolomics in periodontal diseases. Frontiers in Oral Health.

2. Hasturk, H., Kantarci, A., & Van Dyke, T. E. (2020). An evidence-based update on the molecular mechanisms underlying periodontal diseases. International Journal of Molecular Sciences.

3. Huang, M.E. et al. (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72, 567–572

4. Ebersole, J. L., Kirakodu, S., & Novak, M. J. (2020). Salivary omics in periodontal disease: Challenges and opportunities. Periodontology 2000.

5. Bartold, P. M., & Van Dyke, T. E. (2019). An update on the pathophysiology of periodontal tissue destruction. Periodontology 2000.

6. Volodchenko O.A., Podrigalo L.V., Iermakov, Małgorzata S.S., Żychowska T.Z., Jagiełło W. J.BioMed Research International. – 2019.

7.. Маркова К.Л. Диссертация на соискание ученой степени кандидата биологических наук. – Санк Петербург., 2021.

8. Леонова Е.В., Абрамова Н.Е., Туманова С.А., Пастухова А.С. Клиническая стоматология. – 2018.

9. Mahvish K., Anamika Sh., Ananya Sh., Ganesh S., Saif Kh., Saheem A., Ayshah Aysh M.A., Subuhi Sh., Hemlata M., Ahmad A. Journal.Pub.Med.Science. – 2023.

10. Francesca G. B., Tommaso L., Pietro S., Federico V., Marie H., Silvia G., Denise B., Fabio D.F., Roger F, Abdelhamid E. J.TrAC Trends in Analytical Chemistry. – 2020.

11. Emilia Anna Z., Renata Ł., Piotr G., Magdalena N., Aleksandra K., Sławomir Ł. International Journal Molecular Sciences. – 2024.

12. Danilo C., Dolores C.M., Michelangelo C, Valentina P., Anna N.,Claudio M. Fatty acids - from energy substrates to key regulators of cell survival, proliferation and effector function // Cell Stress. – 2019.

13. Carlo C., Gianrico S., Gaetano M., Ranieri M., Michele C., Stefania L. Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis // Journal Clinical Medicine. – 2021.

14. Camilla V.E., Wladimir G.C., Milena M.S., Silvia V.L., Walter L.S., Celso Augusto L.J. Diagnostic potential of saliva proteome analysis: a review and guide to clinical practice // J.Brazilian Oral Research. – 2019.

15. XueLi Ch., Kai W., Yan Z., Kun W. Research progress on post-translational modification of proteins and cardiovascular diseases // Cell Death Discovery. – 2023.

16. Willfried S., Gustavo B.A., Patricia C.T., Anthony B.C. Saliva-Based Test for Detecting Antibodies to Human Immunodeficiency Virus // J.Clin.Diagn.Lab.Immunol. – 1999.

17. Weizhe Xu., Wei Zhou., Huizhi Wang., Shuang Liang. // Advances in Protein Chemistry and Structural Biology. – 2020.

18. Sorsa, T., Tjäderhane, L., & Salo, T. (2018). Matrix metalloproteinases (MMPs) in oral diseases. Oral Diseases.

19. Zhang, Y., Wang, X., & Li, H. (2018). Salivary biomarkers in the diagnosis of periodontal diseases. Journal of Periodontal Research.